JAK3 Janus Kinase Is Involved in Interleukin 7 Signal Pathway

FEBS Lett. 1994 Oct 24;353(3):289-93. doi: 10.1016/0014-5793(94)01065-x.

Abstract

Interleukin (IL) 7 is an important cytokine regulating both T and B cell development and inducing the formation of lymphokine-activated killer cells and cytolytic T lymphocytes. This study reports the role of JAK family kinases in the IL-7 signalling pathway in a T cell clone. The results have shown that out of 4 members of JAK family tyrosine kinases (JAK1, JAK2, JAK3 and Tyk2), only JAK3 was tyrosine-phosphorylated and activated in cells of a T cell clone by stimulation with IL-7. Furthermore, STAT1 alpha (STAT, the signal transducers and activators of transcription) and p44 of MAPK (mitogen-activated protein kinases) were tyrosine phosphorylated by IL-7 stimulation, indicating that the two signal pathways might be involved in IL-7 signal transduction.

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism
  • Cell Line
  • DNA-Binding Proteins / metabolism
  • Enzyme Activation
  • Interleukin-7 / pharmacology*
  • Janus Kinase 3
  • Mice
  • Phosphorylation / drug effects
  • Protein-Tyrosine Kinases / metabolism*
  • Protein-Tyrosine Kinases / pharmacology
  • STAT1 Transcription Factor
  • Signal Transduction / physiology*
  • T-Lymphocytes, Helper-Inducer / physiology
  • Trans-Activators / metabolism
  • Tyrosine / metabolism

Substances

  • DNA-Binding Proteins
  • Interleukin-7
  • STAT1 Transcription Factor
  • Stat1 protein, mouse
  • Trans-Activators
  • Tyrosine
  • Protein-Tyrosine Kinases
  • Jak3 protein, mouse
  • Janus Kinase 3
  • Calcium-Calmodulin-Dependent Protein Kinases