The microhemagglutination assay for Treponema pallidum antibodies (MHA-TP), a new treponemal test for syphilis: where does it fit?

J Am Vener Dis Assoc. 1976 Sep;3(1):3-8.


The status of a new treponemal test, the Microhemagglutination Assay for Treponema pallidum Antibodies (MHA-TP) is reviewed and compared with regard to its sensitivity, specificity, and current clinical application to the VDRL slide test, the most widely used non-treponemal test, and to the manual FTA-ABS test, the standard treponemal test. At present, the MHA-TP test seems to combine the simplicity and lower cost of nontreponemal tests and the sensitivity and specificity of treponemal tests, and thus enjoys features of both a screening and verification procedure. However, additional clinical experience with the test is needed before its role in the serologic diagnosis of syphilis can be conclusively determined.

Publication types

  • Comparative Study

MeSH terms

  • Antibodies, Bacterial / analysis*
  • False Positive Reactions
  • Hemagglutination Tests
  • Humans
  • Immune Adherence Reaction
  • Syphilis Serodiagnosis / methods*
  • Treponema pallidum / immunology*


  • Antibodies, Bacterial