Cloning of cDNA specifically involved in the thyroid cAMP mitogenic pathway

Horm Res. 1994;42(1-2):27-30. doi: 10.1159/000184140.

Abstract

The activation of the cyclic AMP cascade in dog and human thyroid cells in primary culture induces the expression of differentiated gene expression, hyperfunction and proliferation. These programs are developed simultaneously in quiescent dedifferentiated cells. In this paper the strategy followed by our group to define the genes involved in the cAMP mitogenic cascade is outlined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cloning, Molecular*
  • Cyclic AMP / metabolism*
  • DNA, Complementary / genetics*
  • Dogs
  • Genes
  • Humans
  • Mitogens / genetics*
  • Thyroid Gland / cytology
  • Thyroid Gland / metabolism*

Substances

  • DNA, Complementary
  • Mitogens
  • Cyclic AMP