Studies on the cariostatic mechanisms of fluoride

Int Dent J. 1994 Jun;44(3 Suppl 1):263-73.


This paper reviews mechanisms underlying the caries-preventive effects of fluoride, with special reference to factors which govern the efficacy of topical treatments. Fluoride reduces demineralisation in several ways: by reducing bacterial acid production and acidurance; by reducing the equilibrium solubility of apatite; and by the fluoridation of apatite crystal surfaces, reducing the dissolution rate, whether or not there is reduced solubility of the bulk mineral. On available evidence, the last seems to be the most important effect. The effect depends upon the presence of sufficiently high, dissolved fluoride concentrations to maintain the surface fluoridation. The provision of dissolved fluoride is the key to successful therapy, especially topical treatments. Fluoride also promotes remineralisation even at low concentrations, thus slowing or preventing overall mineral loss. The formation of intra-oral fluoride reservoirs capable of supplying ions for a prolonged period is crucial to the success of topical treatments. Such reservoirs include calcium fluoride, formed mainly at tooth surfaces, and fluoride associated with organic components of plaque and oral soft tissues. The patterns of fluoride clearance from intraoral reservoirs are discussed. Fluoride may be present in dentifrices as the fluoride ion (F-) or as the monofluorophosphate ion (FPO3(2-)). It is concluded that the efficacy of FPO3(2-) probably depends on enzymic hydrolysis to F-. Monofluorophosphate appears to be retained less well in intra-oral fluoride reservoirs and reasons for this are discussed.

Publication types

  • Review

MeSH terms

  • Cariostatic Agents / pharmacology*
  • Cariostatic Agents / therapeutic use
  • Dental Caries / prevention & control*
  • Dental Enamel / drug effects
  • Dental Enamel Solubility / drug effects
  • Fluorides / pharmacology*
  • Fluorides / therapeutic use
  • Fluorides, Topical / pharmacology
  • Fluorides, Topical / therapeutic use
  • Humans


  • Cariostatic Agents
  • Fluorides, Topical
  • Fluorides