Oncogene amplifications in early-stage human prostate carcinomas

Int J Cancer. 1994 Dec 1;59(5):637-8. doi: 10.1002/ijc.2910590510.


Oncogene amplifications are frequently found in solid tumours and are often associated with more aggressively growing forms of human cancer. The proto-oncogenes c-myc, c-erbB2/neu and the 11q13 band are the most frequently amplified regions in adenocarcinomas of various origins. The present study was undertaken to define whether c-myc, int2/FGF3 (11q13 region) and c-erbB2/neu genes are involved in prostate tumorigenesis. Tumours and peripheral lymphocyte DNA from 21 localized early-stage prostatic carcinomas were analysed by Southern-blot electrophoresis for amplification of the c-myc and c-erbB2/neu genes and the 11q13 region (int2/FGF3). We detected no amplification of these 3 oncogenes in our panel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / genetics
  • Blotting, Southern
  • DNA, Neoplasm / analysis
  • Fibroblast Growth Factor 3
  • Fibroblast Growth Factors / genetics
  • Gene Amplification*
  • Genes, erbB-2 / genetics
  • Genes, myc / genetics
  • Humans
  • Lymphocytes / chemistry
  • Male
  • Oncogenes / genetics*
  • Prostatic Neoplasms / genetics*
  • Proto-Oncogene Proteins / genetics


  • Biomarkers, Tumor
  • DNA, Neoplasm
  • FGF3 protein, human
  • Fibroblast Growth Factor 3
  • Proto-Oncogene Proteins
  • Fibroblast Growth Factors