WF11899A, B and C, Novel Antifungal Lipopeptides. I. Taxonomy, Fermentation, Isolation and Physico-Chemical Properties

J Antibiot (Tokyo). 1994 Oct;47(10):1084-91. doi: 10.7164/antibiotics.47.1084.

Abstract

WF11899A, B and C, novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899. These compounds belong to the echinocandin type of lipopeptides. Of these compounds, WF11899A showed good solubility in water. These three antibiotics possess potent in vitro antifungal activities against Candida spp.

MeSH terms

  • Animals
  • Antifungal Agents* / chemistry
  • Antifungal Agents* / isolation & purification
  • Antifungal Agents* / pharmacology
  • Candida / drug effects
  • Chemical Phenomena
  • Chemistry, Physical
  • Female
  • Fermentation
  • Lipopeptides
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mice, Inbred ICR
  • Mitosporic Fungi / classification
  • Mitosporic Fungi / metabolism
  • Mitosporic Fungi / ultrastructure
  • Peptides, Cyclic* / biosynthesis
  • Peptides, Cyclic* / chemistry
  • Peptides, Cyclic* / isolation & purification
  • Solubility

Substances

  • Antifungal Agents
  • Lipopeptides
  • Peptides, Cyclic
  • WF 11899A
  • WF 11899C