Suicide in affectively ill adolescents: a case-control study

J Affect Disord. 1994 Jul;31(3):193-202. doi: 10.1016/0165-0327(94)90029-9.


Sixty-three adolescent suicide victims with a history of affective illness were compared to 23 adolescent community controls with a lifetime history of affective illness, using a case-control design. Suicide victims were more likely to have had major depression, comorbid substance abuse, a past suicide attempt, family history of major depression, treatment with a tricyclic antidepressant, history of legal problems, and a handgun available in the home. There was a non-significant trend for bipolar depression to convey a higher risk for completed suicide than unipolar depression. Recommendations for the prevention of suicide among those with early onset affective illness are discussed in light of these findings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Antidepressive Agents, Tricyclic / adverse effects
  • Antidepressive Agents, Tricyclic / therapeutic use
  • Bipolar Disorder / drug therapy
  • Bipolar Disorder / mortality*
  • Bipolar Disorder / psychology
  • Case-Control Studies
  • Cause of Death*
  • Comorbidity
  • Depressive Disorder / drug therapy
  • Depressive Disorder / mortality*
  • Depressive Disorder / psychology
  • Female
  • Humans
  • Male
  • Pennsylvania / epidemiology
  • Retrospective Studies
  • Risk Factors
  • Suicide / psychology
  • Suicide / statistics & numerical data*
  • Suicide Prevention


  • Antidepressive Agents, Tricyclic