A radiological analysis of heart sympathetic functions with meta-[123I]iodobenzylguanidine in neurological patients with autonomic failure

J Auton Nerv Syst. 1994 Sep;49(1):81-4. doi: 10.1016/0165-1838(94)90023-x.


Cardiac scintigraphy with meta-[123I]iodobenzylguanidine (MIBG) is used to assess cardiac sympathetic function. We performed [123I]MIBG scintigraphy in 7 patients with neurological diseases presenting orthostatic hypotension and other autonomic failures (AF), 22 neurological patients without AF, and 9 healthy subjects. Thallium scintigraphy and echocardiography were also performed in all subjects. In this series, patients with any evidence of cardiac dysfunction were excluded. No [123I]MIBG accumulation was observed in all patients with AF, and cardiac defects were noted in 7 patients (5 with Parkinson's disease [PD], 2 with spinocerebellar degenerations [SCD]), and in some patients without AF. In contrast, the distribution of [123I]MIBG was normal in all the healthy subjects. No decrease in [123I]MIBG accumulation was resulted from drug therapy (droxidopa, amezinium and thyrotropin-releasing hormone). In conclusion, reduced accumulation on [123I]MIBG scintigraphy may be due to myocardial beta-adrenoceptor dysfunction or reduced central sympathetic activity of the heart, or both.

Publication types

  • Clinical Trial

MeSH terms

  • 3-Iodobenzylguanidine
  • Aged
  • Autonomic Nervous System Diseases / diagnostic imaging*
  • Echocardiography
  • Female
  • Heart / diagnostic imaging*
  • Heart / physiopathology
  • Humans
  • Hypotension, Orthostatic / diagnostic imaging
  • Hypotension, Orthostatic / physiopathology
  • Iodine Radioisotopes
  • Iodobenzenes*
  • Male
  • Middle Aged
  • Myocardium / metabolism
  • Norepinephrine / metabolism
  • Radionuclide Imaging
  • Sympathetic Nervous System / diagnostic imaging*
  • Sympathetic Nervous System / drug effects
  • Sympatholytics*
  • Thallium


  • Iodine Radioisotopes
  • Iodobenzenes
  • Sympatholytics
  • 3-Iodobenzylguanidine
  • Thallium
  • Norepinephrine