Antiphospholipid syndrome as the second cause of non-tumorous Budd-Chiari syndrome

J Hepatol. 1994 Jul;21(1):76-80. doi: 10.1016/s0168-8278(94)80140-1.


In a prospective study of 22 patients with non-tumorous Budd-Chiari syndrome, four were found to have the antiphospholipid syndrome with no other cause of hepatic vein thrombosis. All four patients were young women. The antiphospholipid syndrome was secondary to systemic lupus in one case, to a "lupus-like disease" in another, and apparently primary in the remaining two cases. Two patients died. The other two are in good health on chronic oral anticoagulation. In our experience, the antiphospholipid syndrome is a frequent cause, after myeloproliferative disorders, of non-tumorous Budd-Chiari syndrome. In such patients, long-term anticoagulation may prevent recurrence or extension of thrombosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Antiphospholipid / blood
  • Antiphospholipid Syndrome / diagnosis*
  • Autoantibodies / blood
  • Budd-Chiari Syndrome / etiology*
  • DNA / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / diagnosis
  • Male
  • Prospective Studies


  • Antibodies, Antiphospholipid
  • Autoantibodies
  • DNA