Taurine amplifies renal kallikrein and prevents salt-induced hypertension in Dahl rats

J Hypertens. 1994 Jun;12(6):653-61.


Objective: To determine whether taurine reduces blood pressure by stimulating the renal kallikrein-kinin system.

Methods: The effects of taurine on blood pressure, urinary kallikrein activity and renal kallikrein gene expression were investigated in Dahl salt-sensitive (Dahl-S) rats. The specificity of the action of taurine was verified by comparison with the action of beta-alanine, a carboxylic analogue of taurine. The effect of co-administration of the specific bradykinin B2 receptor antagonist Hoe 140 was also examined.

Results: Administration of taurine (3% in drinking water) for 4 weeks retarded the development of salt (4% sodium chloride diet)-induced hypertension. Systolic blood pressure at the end of the experiment was significantly higher in control rats than in taurine-treated rats. Urinary sodium excretion was not decreased by the reduction in blood pressure. The heart weight:body weight ratio was significantly lower, and urinary volume and kallikrein excretion were significantly higher, in taurine-treated rats. Renal kallikrein gene expression at weeks 1 and 4 was higher in taurine-treated rats. Systolic blood pressure 3 and 4 weeks after the administration of beta-alanine was slightly, but not significantly, lower than that of untreated rats on a high-salt diet, and was accompanied by a significantly lower body weight. Urinary kallikrein excretion decreased with a high-salt diet regardless of beta-alanine administration. Continuous systemic administration of Hoe 140 did not cause any significant alteration in blood pressure in Dahl-S rats that received taurine with a high-salt diet. Taurine also showed a renoprotective effect, as judged by a reduction in proteinuria.

Conclusion: These results suggest that taurine is an effective antihypertensive agent for salt-induced hypertension. Although taurine activated renal kallikrein, further studies are required to confirm the participation of activated kallikrein in the antihypertensive, cardioprotective and renoprotective effects of taurine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Bradykinin / analogs & derivatives
  • Bradykinin / pharmacology
  • Gene Expression / drug effects
  • Hypertension / prevention & control*
  • Kallikreins / biosynthesis
  • Kallikreins / genetics
  • Kallikreins / urine*
  • Kidney / drug effects
  • Kidney / metabolism*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Sodium Chloride / pharmacology*
  • Taurine / pharmacology*
  • beta-Alanine / pharmacology


  • beta-Alanine
  • Taurine
  • Sodium Chloride
  • icatibant
  • Kallikreins
  • Bradykinin