Autonomic disturbance in severe tetanus: failure of parenteral clonidine to control blood pressure

J Infect. 1994 Jul;29(1):67-71. doi: 10.1016/s0163-4453(94)95114-4.

Abstract

In this paper we describe a typical case of tetanus and report our observations with the centrally acting alpha 2-adrenoreceptor agonist clonidine. Previous work with this agent has suggested that it may be of value in tetanus.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Autonomic Nervous System Diseases / etiology*
  • Blood Pressure / drug effects*
  • Clonidine / administration & dosage
  • Clonidine / pharmacology*
  • Clonidine / therapeutic use
  • Humans
  • Hypertension / drug therapy
  • Hypertension / etiology
  • Injections, Intravenous
  • Male
  • Paralysis / etiology
  • Penicillin G / administration & dosage
  • Penicillin G / therapeutic use
  • Tetanus / complications*
  • Tetanus / drug therapy

Substances

  • Clonidine
  • Penicillin G