Effect of clonidine on postpartum shivering after epidural analgesia: a randomized, controlled, double-blind study

J Pain Symptom Manage. 1994 Jul;9(5):294-7. doi: 10.1016/0885-3924(94)90186-4.


In obstetric patients treated with epidural analgesia during labor and delivery, shivering is quite frequent due to stress, vasodilatation, infusion of fluids, low ambient temperature, and the direct effect of solution injected into the epidural space. Sixty obstetric patients who developed shivering after receiving epidural analgesia for delivery were randomly assigned to treatment with clonidine 0.150 mg i.v. (N = 20), meperidine 50 mg i.v. (N = 20), or saline solution (N = 20). Drug administration was double blind. The effect on shivering (graded as all or none), drowsiness, heart rate, and systolic arterial pressure was evaluated 5 min after the study drug was administered. Clonidine was as effective as meperidine in controlling shivering and caused a greater reduction in heart rate. Drowsiness occurred after clonidine as well as meperidine. Thus, clonidine proved to be effective in controlling shivering and adrenergic response after delivery using epidural analgesia and produced an acceptable level of drowsiness.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analgesia, Epidural / adverse effects*
  • Clonidine / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Meperidine / therapeutic use
  • Postpartum Period / physiology*
  • Shivering / drug effects*


  • Meperidine
  • Clonidine