High incidence of H-ras oncogene mutations in squamous cell carcinoma of lip vermilion

J Oral Pathol Med. 1994 Aug;23(7):298-301. doi: 10.1111/j.1600-0714.1994.tb00065.x.


Nine specimens of well-differentiated squamous cell carcinoma of the lip vermilion have been analyzed for the presence of H-ras oncogene mutations, using the technique of hybridization with synthetic oligonucleotide probes on in vitro amplified tumour DNA. Five specimens harbored mutations: four in codon 12 and one in codon 13. This high incidence (55%) of mutated H-ras genes suggests that their activation may play an important role in lip tumour development and may be connected to the exposure to chemical and/or physical carcinogens.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Base Sequence
  • Carcinoma, Squamous Cell / genetics*
  • DNA, Neoplasm / genetics
  • Female
  • Genes, ras / genetics*
  • Glycine / genetics
  • Humans
  • Lip Neoplasms / genetics*
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • Point Mutation*
  • Polymerase Chain Reaction


  • DNA, Neoplasm
  • Oligonucleotide Probes
  • Glycine