Clinical utility and serological connections of anti-RA33 antibodies in systemic lupus erythematosus

J Rheumatol. 1994 Jul;21(7):1260-3.

Abstract

Objective: To determine whether the autoantibody anti-RA33, first identified in patients with rheumatoid arthritis, could define a subset of patients with lupus.

Methods: Sera from 30 patients with systemic lupus erythematosus (SLE), including serial bleeds from 8 patients were tested for anti-RA33 antibodies by immunoblotting. The results were compared to a wide range of SLE clinical features using the British Isles Lupus Assessment Group system and serological abnormalities.

Results: 12 of the 30 patients had RA33 antibodies. Their presence was associated with erosive arthropathy, and a lack of dermatological involvement in patients less likely to be Caucasian.

Conclusion: The presence of anti-RA33 antibodies appears to identify a subset of patients with SLE.

MeSH terms

  • Antigens, Nuclear
  • Autoantibodies / analysis*
  • European Continental Ancestry Group
  • Humans
  • Immunoblotting
  • Lupus Erythematosus, Systemic / diagnosis*
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Erythematosus, Systemic / physiopathology
  • Nuclear Proteins / immunology*
  • Serologic Tests*

Substances

  • Antigens, Nuclear
  • Autoantibodies
  • Nuclear Proteins