Efficacy of single-dose therapy of urinary tract infection in infants and children: a review

J Natl Med Assoc. 1994 Sep;86(9):690-6.


The role of single-dose therapy was evaluated by pooling data on 320 infants and children included in 12 clinical trials that differed from each other in many variables. Single-dose therapy achieved an overall cure rate of 89%, but varied with different antimicrobial agents. Intramuscular aminoglycosides were the best (cure rate: 96%) closely followed by trimethoprim-sulfamethoxazole or a sulfa drug with a cure rate of 90%. The cure rate with amoxicillin (75%) was significantly less. Single-dose therapy was most effective (cure rate: 90%) in well-documented lower urinary tract infections (UTIs) and slightly less effective (cure rate: 89%) among those in whom upper UTI could not be excluded. In patients with a normal urinary tract, single-dose therapy was significantly more effective (cure rate: 93%) than in the group of 36 patients with a urinary tract malformation (cure rate: 69%). Single-dose therapy can be used with confidence in patients with lower UTIs and in those with normal urinary tracts. In patients with abnormal urinary tracts and lower UTIs, single-dose therapy may be used with caution, preferably using aminoglycosides. Further studies are required to establish a definitive role of single-dose therapy in patients with urinary tract malformation.

Publication types

  • Meta-Analysis

MeSH terms

  • Adolescent
  • Anti-Infective Agents, Urinary / administration & dosage*
  • Anti-Infective Agents, Urinary / therapeutic use
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Treatment Outcome
  • Urinary Tract Infections / drug therapy*


  • Anti-Infective Agents, Urinary