Abstract
We investigated the possible renal protective effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), an adenosine A1-receptor antagonist, against gentamicin (GM)-induced acute renal failure (ARF) in rats. ARF was induced by subcutaneous injection of GM at 80 mg/kg/day for 12 days. KW-3902 (0.001-0.1 mg/kg, p.o., twice daily) attenuated the increases of serum creatinine and urea nitrogen and the decrease of creatinine clearance in rats treated with GM. In contrast, furosemide and trichlormethiazide aggravated the GM-induced nephrotoxicity. These results suggest that KW-3902 can ameliorate the GM-induced ARF and that endogenous adenosine may be involved in GM-induced ARF via the adenosine A1-receptor.
MeSH terms
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Acute Kidney Injury / chemically induced
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Acute Kidney Injury / drug therapy
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Acute Kidney Injury / prevention & control*
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Administration, Oral
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Animals
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Disease Models, Animal
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Furosemide / administration & dosage
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Furosemide / pharmacology
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Furosemide / therapeutic use
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Gentamicins / administration & dosage
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Gentamicins / toxicity*
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Injections, Subcutaneous
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Kidney / drug effects*
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Kidney / pathology
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Male
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Purinergic P1 Receptor Antagonists*
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Rats
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Rats, Wistar
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Trichlormethiazide / administration & dosage
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Trichlormethiazide / pharmacology
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Trichlormethiazide / therapeutic use
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Xanthines / administration & dosage
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Xanthines / pharmacology
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Xanthines / therapeutic use*
Substances
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Gentamicins
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Purinergic P1 Receptor Antagonists
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Xanthines
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rolofylline
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Furosemide
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Trichlormethiazide