Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

Nature. 1994 Nov 17;372(6503):237-43. doi: 10.1038/372237a0.

Abstract

Metabotropic glutamate receptor 1 (mGluR1) is a member of a large family of G-protein-coupled glutamate receptors, the physiological functions of which are largely unknown. Mice deficient in mGluR1 have severe motor coordination and spatial learning deficits. They have no gross anatomical or basic electrophysiological abnormalities in either the cerebellum or hippocampus, but they show impaired cerebellar long-term depression and hippocampal mossy fibre long-term potentiation. mGluR1-deficient mice should therefore be valuable models for studying synaptic plasticity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cell Line
  • Cerebellum / pathology
  • Cerebellum / physiopathology
  • Electrophysiology
  • Female
  • Hippocampus / pathology
  • Hippocampus / physiopathology
  • Learning Disabilities / genetics
  • Long-Term Potentiation
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Motor Activity
  • Mutagenesis
  • Neuromuscular Diseases / genetics*
  • Neuromuscular Diseases / pathology
  • Neuromuscular Diseases / physiopathology
  • Neuronal Plasticity / physiology*
  • Oligodeoxyribonucleotides
  • Purkinje Cells / physiology
  • Receptors, Metabotropic Glutamate / agonists
  • Receptors, Metabotropic Glutamate / deficiency
  • Receptors, Metabotropic Glutamate / genetics
  • Receptors, Metabotropic Glutamate / physiology*
  • Synapses / physiology*

Substances

  • Oligodeoxyribonucleotides
  • Receptors, Metabotropic Glutamate