Gene inhibition using antisense oligodeoxynucleotides

Nature. 1994 Nov 24;372(6504):333-5. doi: 10.1038/372333a0.


Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specific gene inhibition. This review critically evaluates recent progress in the development of antisense ODNs.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression / drug effects*
  • Humans
  • Oligonucleotides, Antisense / pharmacology*


  • Oligonucleotides, Antisense