Prolonged penile erections induced by hydroxyzine: possible mechanism of action

Neuropsychobiology. 1994;30(1):4-6. doi: 10.1159/000119126.

Abstract

We describe a subject who developed prolonged penile erections on hydroxyzine. Molecular modelling showed that the hydroxyzine metabolite, norchlorcyclizine, has structural and conformational similarities to the trazodone metabolite, m-chlorophenylpiperazine. This suggests that a common pharmacological mechanism may underlie the ability of trazodone and hydroxyzine to induce erections.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Humans
  • Hydroxyzine / adverse effects*
  • Hydroxyzine / pharmacokinetics
  • Hydroxyzine / therapeutic use
  • Insect Bites and Stings / blood
  • Insect Bites and Stings / drug therapy*
  • Male
  • Models, Molecular
  • Molecular Conformation
  • Piperazines / adverse effects
  • Piperazines / pharmacokinetics
  • Priapism / chemically induced*
  • Serotonin Receptor Agonists / adverse effects
  • Serotonin Receptor Agonists / pharmacokinetics
  • Structure-Activity Relationship
  • Trazodone / adverse effects
  • Trazodone / pharmacokinetics

Substances

  • Piperazines
  • Serotonin Receptor Agonists
  • Hydroxyzine
  • 1-(3-chlorophenyl)piperazine
  • Trazodone