Abstract
We describe a subject who developed prolonged penile erections on hydroxyzine. Molecular modelling showed that the hydroxyzine metabolite, norchlorcyclizine, has structural and conformational similarities to the trazodone metabolite, m-chlorophenylpiperazine. This suggests that a common pharmacological mechanism may underlie the ability of trazodone and hydroxyzine to induce erections.
MeSH terms
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Adult
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Humans
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Hydroxyzine / adverse effects*
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Hydroxyzine / pharmacokinetics
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Hydroxyzine / therapeutic use
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Insect Bites and Stings / blood
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Insect Bites and Stings / drug therapy*
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Male
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Models, Molecular
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Molecular Conformation
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Piperazines / adverse effects
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Piperazines / pharmacokinetics
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Priapism / chemically induced*
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Serotonin Receptor Agonists / adverse effects
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Serotonin Receptor Agonists / pharmacokinetics
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Structure-Activity Relationship
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Trazodone / adverse effects
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Trazodone / pharmacokinetics
Substances
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Piperazines
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Serotonin Receptor Agonists
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Hydroxyzine
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1-(3-chlorophenyl)piperazine
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Trazodone