Enhanced responses of rat dorsal horn neurons after UV irradiation of the hindpaw; roles of the NMDA receptor

Neurosci Lett. 1994 Jul 18;176(1):41-4. doi: 10.1016/0304-3940(94)90866-4.

Abstract

Recordings were made from nociceptive dorsal horn neurones in the anaesthetized rat 3 and 5 days after ultraviolet (UV) irradiation of the hindpaw. The electrically evoked A beta-fibre-evoked responses from the paw were enhanced and their thresholds were lowered. Spontaneous neuronal activity was increased but the C-fibre-evoked responses were unaltered. These enhanced responses, suggestive of allodynia, were reduced by N-methyl-D-aspartate receptor (NMDA) antagonism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / radiation effects
  • Analysis of Variance
  • Animals
  • Electric Stimulation
  • Evoked Potentials / radiation effects*
  • Female
  • Hindlimb / innervation*
  • Injections, Spinal
  • Kynurenic Acid / administration & dosage
  • Kynurenic Acid / analogs & derivatives*
  • Kynurenic Acid / pharmacology
  • Neurons / physiology
  • Neurons / radiation effects*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Receptors, N-Methyl-D-Aspartate / physiology*
  • Sensory Thresholds
  • Spinal Cord / physiology
  • Spinal Cord / radiation effects*
  • Time Factors
  • Ultraviolet Rays*

Substances

  • Receptors, N-Methyl-D-Aspartate
  • Kynurenic Acid
  • 7-chlorokynurenic acid