Abstract
Recordings were made from nociceptive dorsal horn neurones in the anaesthetized rat 3 and 5 days after ultraviolet (UV) irradiation of the hindpaw. The electrically evoked A beta-fibre-evoked responses from the paw were enhanced and their thresholds were lowered. Spontaneous neuronal activity was increased but the C-fibre-evoked responses were unaltered. These enhanced responses, suggestive of allodynia, were reduced by N-methyl-D-aspartate receptor (NMDA) antagonism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / radiation effects
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Analysis of Variance
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Animals
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Electric Stimulation
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Evoked Potentials / radiation effects*
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Female
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Hindlimb / innervation*
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Injections, Spinal
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Kynurenic Acid / administration & dosage
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Kynurenic Acid / analogs & derivatives*
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Kynurenic Acid / pharmacology
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Neurons / physiology
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Neurons / radiation effects*
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Rats
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Rats, Sprague-Dawley
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Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
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Receptors, N-Methyl-D-Aspartate / physiology*
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Sensory Thresholds
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Spinal Cord / physiology
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Spinal Cord / radiation effects*
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Time Factors
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Ultraviolet Rays*
Substances
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Receptors, N-Methyl-D-Aspartate
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Kynurenic Acid
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7-chlorokynurenic acid