Usefulness of 99Tcm-N,N'-ethylene-1-dicysteine complex for dynamic kidney investigations

Nucl Med Commun. 1994 Aug;15(8):628-35. doi: 10.1097/00006231-199408000-00007.


To assess the usefulness of the 99Tcm-N,N'-ethylene-1-dicysteine (99Tcm-EC) complex for examination of kidney function, dynamic kidney scintigraphy with 99Tcm-EC and clearance determinations were performed. During renoscintigraphy the kidney images were of superb quality, with overlying organs (liver, spleen) not visualized. Renograms showed typical shapes, their Tmax and T1/2 values being unsignificantly different from the values obtained with other radiopharmaceuticals used in renoscintigraphy (mercaptoacetyl triglycine, hippuran). Very strict correlations were found between values of 99Tcm-EC and 131I-iodohippurate (OIH) clearances (r = 0.91) and excretion rate constants (r = 0.92) for both radiopharmaceuticals. The correlation enabled the formulation of an equation by which effective renal plasma flow (ERPF) could be established from 99Tcm-EC clearance: ERPFOIH = 1.245 x ClEC + 51.52. On the basis of this equation a lower boundary of the normal 99Tcm-EC clearance was established; it amounts to 300 ml min-1 1.73 m-2.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Animals
  • Blood Proteins / metabolism
  • Cysteine / analogs & derivatives*
  • Female
  • Humans
  • Iodine Radioisotopes
  • Iodohippuric Acid
  • Kidney / diagnostic imaging*
  • Kidney / physiology
  • Kidney / physiopathology
  • Metabolic Clearance Rate
  • Mice
  • Mutagenicity Tests
  • Organotechnetium Compounds*
  • Radionuclide Imaging
  • Reagent Kits, Diagnostic
  • Renal Plasma Flow, Effective


  • Blood Proteins
  • Iodine Radioisotopes
  • Organotechnetium Compounds
  • Reagent Kits, Diagnostic
  • technetium Tc 99m-ethylenedicysteine
  • Iodohippuric Acid
  • Cysteine