Mitomycin C as adjunctive therapy with glaucoma implant surgery

Ophthalmic Surg. 1994 Jul;25(7):458-62.


Twenty-one eyes of 21 patients with refractory glaucoma underwent glaucoma surgery involving placement of a modified Molteno implant and intraoperative application of mitomycin C. Sixteen eyes (76.2%) had an intraocular pressure (IOP) of 21 mm Hg or less after a mean follow up of 9.4 +/- 6.4 months; additional medication was needed in six eyes. Major complications included early flat anterior chamber (42.9%), implant plate erosion (9.5%), tube erosion (4.8%), late hypotony (4.8%), tube-corneal touch (4.8%), and phthisis bulbi after choroidal hemorrhage (4.8%). Only one patient had a high IOP due to decreased filtration through the implant. These results suggest that glaucoma implant surgery with the adjunctive use of mitomycin C may be useful in eyes with refractory glaucoma.

MeSH terms

  • Adult
  • Aged
  • Biocompatible Materials
  • Chemotherapy, Adjuvant
  • Female
  • Fibrosis / drug therapy
  • Follow-Up Studies
  • Glaucoma / surgery*
  • Humans
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Mitomycin / therapeutic use*
  • Molteno Implants*
  • Postoperative Complications / drug therapy
  • Prognosis
  • Silicone Elastomers


  • Biocompatible Materials
  • Silicone Elastomers
  • Mitomycin