Loss of nitroglycerin from intravenous infusion sets

Lancet. 1978 Aug 12;2(8085):349-50. doi: 10.1016/s0140-6736(78)92945-8.

Abstract

During initial studies with nitroglycerin infusion in patients with acute myocardial infarction, higher doses than previously reported were required to achieve the desired haemodynamic effect. A flow-rate-dependent loss of drug from the plastic infusion set was demonstrated during simulated infusion. This loss was considerably reduced when nitroglycerin was infused from glass syringes through high-density polyethylene tubing.

Publication types

  • Comparative Study

MeSH terms

  • Acute Disease
  • Diffusion
  • Drug Interactions
  • Glass
  • Humans
  • Infusions, Parenteral / instrumentation
  • Myocardial Infarction / drug therapy*
  • Nitroglycerin / administration & dosage*
  • Polyethylenes / pharmacology
  • Rheology
  • Syringes

Substances

  • Polyethylenes
  • Nitroglycerin