Mentholated cigarettes decrease puff volume of smoke and increase carbon monoxide absorption

Physiol Behav. 1994 Sep;56(3):563-70. doi: 10.1016/0031-9384(94)90302-6.


The influence of mentholated vs. regular cigarettes on selected chemical and topographic parameters was measured in 20 smokers in a pulmonary function laboratory. Half the subjects were black and half were white; half were menthol and half regular smokers. All subjects smoked both types of cigarettes, one on each of 2 days. Compared to regular cigarettes, mentholated cigarettes produced a significantly greater boost in carbon monoxide measured as both blood carboxyhemoglobin and end-expired carbon monoxide, despite the fact that mentholated cigarettes decreased average and total cumulative puff volumes and increased mean puff flow rates of inhaled smoke. These chemical and topographic differences were independent of race. No significant differences in depth of inhalation of the smoke or in the amount of insoluble smoke particulates delivered to or retained in the respiratory tract were noted between the two types of cigarettes. Mentholation of cigarettes may decrease volume of smoke inhaled but appears to increase exposure of smokers to toxic effects of carbon monoxide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Carbon Monoxide / pharmacokinetics*
  • Carboxyhemoglobin / metabolism
  • Humans
  • Male
  • Menthol / pharmacology*
  • Middle Aged
  • Smoking / physiopathology*


  • Menthol
  • Carbon Monoxide
  • Carboxyhemoglobin