We studied the electrodermal skin conductance responses (SCRs) of 36 subjects with well-characterized lesions in various regions of the cerebral hemispheres. Several lesion loci were consistently associated with defective electrodermal responding: the ventromedial frontal region (right and left), the right inferior parietal region, and the anterior cingulate gyrus (right and left). Our findings provide direct information regarding neural correlates of skin conductance responses in humans.