Risk factors for bone loss in chronic active hepatitis and primary biliary cirrhosis

Scand J Gastroenterol. 1994 Aug;29(8):753-6. doi: 10.3109/00365529409092505.

Abstract

Background: Data on risk factors for bone loss in chronic active hepatitis (CAH) and primary biliary cirrhosis (PBC) are scanty and/or conflicting.

Methods: Bone mineral density (BMD) in the distal forearm was measured using single-photon absorptiometry in 39 patients with CAH and 32 patients with PBC. We also attempted to identify risk factors for bone loss by means of a questionnaire and through a wide range of biochemical analyses.

Results: In the CAH patients BMD is inversely related to the duration of steroid treatment and to age at menarche. In the PBC patients there was a strong correlation between BMD and serum gastrin concentrations.

Conclusions: Bone loss in CAH is to some extent explained by steroid treatment and delayed menarche. Bone loss in PBC may be reduced by increased calcitonin secretion induced by gastrocalcin.

Publication types

  • Comparative Study

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Autoimmune Diseases / complications
  • Bone Density
  • Diet
  • Female
  • Gastrins / blood
  • Hepatitis C / complications
  • Hepatitis, Chronic / complications*
  • Humans
  • Liver Cirrhosis, Biliary / complications*
  • Male
  • Menarche
  • Middle Aged
  • Osteoporosis / diagnostic imaging
  • Osteoporosis / epidemiology*
  • Osteoporosis / etiology
  • Radionuclide Imaging
  • Risk Factors

Substances

  • Adrenal Cortex Hormones
  • Gastrins