doi: 10.1126/science.7973637.
DNA loop repair by human cell extracts
Affiliations
- PMID: 7973637
- DOI: 10.1126/science.7973637
Item in Clipboard
DNA loop repair by human cell extracts
Science.
.
Abstract
An activity in human cell extracts is described that repairs DNA with loops of five or more unpaired bases. Repair is strand-specific and is directed by a nick located 5' or 3' to the loop. This repair is observed in a colorectal cancer cell line that is devoid of a wild-type hMLH1 gene and is deficient in repair of mismatches. However, a cell line with deletions in both hMSH2 alleles is deficient in repair of both loops and mismatches. Defects in loop repair may be relevant to the repetitive-sequence instability observed in cancers and other hereditary diseases.
Comment in
-
DNA repair comes into its own.Science. 1994 Nov 4;266(5186):728-30. doi: 10.1126/science.7973626. Science. 1994. PMID: 7973626 No abstract available.
Similar articles
-
Allele loss occurs frequently at hMLH1, but rarely at hMSH2, in sporadic colorectal cancers with microsatellite instability.Br J Cancer. 1996 Nov;74(10):1514-7. doi: 10.1038/bjc.1996.582. Br J Cancer. 1996. PMID: 8932328 Free PMC article.
-
Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: identification of three novel germ-line mutations in promoter of the hMSH2 gene.Cancer Res. 2002 Jan 1;62(1):38-42. Cancer Res. 2002. PMID: 11782355
-
Binding of mismatched microsatellite DNA sequences by the human MSH2 protein.Science. 1994 Nov 25;266(5189):1403-5. doi: 10.1126/science.7973733. Science. 1994. PMID: 7973733
-
Appropriate partners make good matches.Science. 1995 Jun 30;268(5219):1857-8. doi: 10.1126/science.7604258. Science. 1995. PMID: 7604258 Review. No abstract available.
-
Molecular diagnostics of cancer predisposition: hereditary non-polyposis colorectal carcinoma and mismatch repair defects.Biochim Biophys Acta. 1999 May 31;1423(3):O1-O10. doi: 10.1016/s0304-419x(99)00008-6. Biochim Biophys Acta. 1999. PMID: 10382540 Review.
Cited by
-
FAN1 removes triplet repeat extrusions via a PCNA- and RFC-dependent mechanism.Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2302103120. doi: 10.1073/pnas.2302103120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549289 Free PMC article.
-
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. Epub 2021 Oct 14. Cell. 2021. PMID: 34653350 Free PMC article.
-
DNA Mismatch Repair and its Role in Huntington's Disease.J Huntingtons Dis. 2021;10(1):75-94. doi: 10.3233/JHD-200438. J Huntingtons Dis. 2021. PMID: 33579865 Free PMC article. Review.
-
The mechanism of gene targeting in human somatic cells.PLoS Genet. 2014 Apr 3;10(4):e1004251. doi: 10.1371/journal.pgen.1004251. eCollection 2014 Apr. PLoS Genet. 2014. PMID: 24699519 Free PMC article.
-
Impact of bulge loop size on DNA triplet repeat domains: Implications for DNA repair and expansion.Biopolymers. 2014 Jan;101(1):1-12. doi: 10.1002/bip.22236. Biopolymers. 2014. PMID: 23494673 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
