The LIM domain: a new structural motif found in zinc-finger-like proteins

Trends Genet. 1994 Sep;10(9):315-20. doi: 10.1016/0168-9525(94)90034-5.


An important new family of proteins has recently been described that carries a novel cysteine-rich zinc-binding domain called the LIM domain. This protein family is present in mammals, amphibians, flies, worms and plants and its main function is in developmental regulation. Although a role in protein-protein interaction seems likely, intriguing similarities to GATA zinc fingers imply that the LIM domain may also be involved in binding to specific nucleic acids.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • Molecular Sequence Data
  • Protein Binding
  • Proteins / chemistry*
  • Proteins / genetics
  • Sequence Homology, Amino Acid
  • Zinc Fingers*


  • DNA-Binding Proteins
  • Proteins