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Review
, 10 (9), 315-20

The LIM Domain: A New Structural Motif Found in Zinc-Finger-Like Proteins

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Review

The LIM Domain: A New Structural Motif Found in Zinc-Finger-Like Proteins

I Sánchez-García et al. Trends Genet.

Abstract

An important new family of proteins has recently been described that carries a novel cysteine-rich zinc-binding domain called the LIM domain. This protein family is present in mammals, amphibians, flies, worms and plants and its main function is in developmental regulation. Although a role in protein-protein interaction seems likely, intriguing similarities to GATA zinc fingers imply that the LIM domain may also be involved in binding to specific nucleic acids.

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