Hard-palate mucosa graft in Stevens-Johnson syndrome

Am J Ophthalmol. 1994 Dec 15;118(6):786-91. doi: 10.1016/s0002-9394(14)72559-0.


Purpose: We evaluated the use of hard-palate mucosa grafts in the treatment of cicatricial entropion and trichiasis associated with Stevens-Johnson syndrome.

Methods: Six patients, two men and four women, were treated with hard-palate mucosa grafts of one or more eyelids with cicatricial entropion, trichiasis, and corneal disease. The follow-up ranged from 19 to 33 months.

Results: Visual acuity improved in one of nine eyes and remained stable in the rest. Corneal epithelial disease improved in eight of nine eyes, while in one eye the epithelial defect stabilized. The corneal epithelium of all three corneal transplants remained intact, although one of these patients underwent another corneal transplantation and the other two transplants opacified from rejection. Cicatricial entropion resolved and symblephara improved in all 16 eyelids. Trichiasis resolved or improved in 12 of 16 eyelids and remained stable in the other eyelids.

Conclusions: The chronic relapsing nature of Stevens-Johnson syndrome requires caution in interpreting surgical intervention in the treatment of dysfunctional eyelids. However, hard-palate grafts may be considered for patients with the Stevens-Johnson syndrome and severe ocular surface disease.

MeSH terms

  • Adult
  • Aged
  • Cicatrix / etiology
  • Cicatrix / surgery*
  • Corneal Diseases / etiology
  • Corneal Diseases / surgery
  • Entropion / etiology
  • Entropion / surgery*
  • Eyelashes / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Mucous Membrane / transplantation*
  • Palate / surgery*
  • Stevens-Johnson Syndrome / complications*