Further investigations on the mode of entry of vaccinia virus into cells

J Gen Virol. 1976 Aug;32(2):275-82. doi: 10.1099/0022-1317-32-2-275.


Earlier results indicating that vaccinia virus entered L cells by a process of direct fusion between the virus envelope and the plasma membrane of the cell have been confirmed and extended using immuno-ferritin conjugates to locate virus antigens on the host cell surface. After fusion, components of the virus envelope become rapidly dispersed in the plasma membrane. Fusion has also been observed as the predominant mode of entry of vaccinia virus into HeLa cells.

MeSH terms

  • Adsorption
  • Antigens, Viral / isolation & purification
  • Cell Membrane / immunology
  • Cell Membrane / microbiology
  • Ferritins
  • HeLa Cells
  • Immunologic Techniques
  • L Cells
  • Vaccinia virus / growth & development*
  • Vaccinia virus / immunology


  • Antigens, Viral
  • Ferritins