Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 Nov 15;204(3):1016-22.
doi: 10.1006/bbrc.1994.2564.

The Tetratricopeptide Repeat-Domain of the PAS10 Protein of Saccharomyces Cerevisiae Is Essential for Binding the Peroxisomal Targeting signal-SKL

Affiliations

The Tetratricopeptide Repeat-Domain of the PAS10 Protein of Saccharomyces Cerevisiae Is Essential for Binding the Peroxisomal Targeting signal-SKL

C Brocard et al. Biochem Biophys Res Commun. .

Abstract

The PAS10 gene was found in a two-hybrid screen for the isolation of genes encoding proteins which interact with the C-terminal peroxisomal targeting signal -SKL. The PAS10 protein is known to be involved in import of proteins into peroxisomes and to contain a tetratricopeptide repeat (TPR) domain. All TPR-containing proteins involved in diverse processes like mitosis or RNA-synthesis share the ability to interact with other proteins. Here we show that the PAS10 protein interacts in vivo with the C-terminal peroxisomal targeting signal. The part essential for this interaction contains the complete tetratricopeptide repeat domain.

Similar articles

See all similar articles

Cited by 37 articles

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources

Feedback