Exposure of simian virus-40-transformed human cells to magnetic fields results in increased levels of T-antigen mRNA and protein

Bioelectromagnetics. 1994;15(4):329-36. doi: 10.1002/bem.2250150407.


In its integrated form. SV-40 DNA offers an opportunity to observe the behavior of what is in effect a viral genome within a cellular genome, with transcriptional and translational products that can be clearly distinguished from those of the host cell. Exposure of SV40-transformed human fibroblasts to a 60 Hz continuous-wave sinusoidal electromagnetic (EM) field resulted in increased levels of virally derived mRNA and protein of large T-antigen. These findings provide evidence that a foreign DNA integrated into cells can be affected by EM fields under conditions known to cause increased transcripts from endogenous cellular genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antigens, Viral, Tumor / biosynthesis*
  • Blotting, Western
  • Cell Line
  • Cell Line, Transformed / radiation effects
  • Fibroblasts / metabolism
  • Fibroblasts / radiation effects
  • Gene Expression / radiation effects*
  • Humans
  • Magnetics*
  • RNA, Messenger / biosynthesis*
  • Simian virus 40 / genetics*
  • Transcription, Genetic / radiation effects


  • Antigens, Viral, Tumor
  • RNA, Messenger