IL-2 receptor alpha chain expression during early B lymphocyte differentiation

Int Immunol. 1994 Aug;6(8):1265-8. doi: 10.1093/intimm/6.8.1265.


The IL-2/IL-2 receptor (IL-2R) has been studied intensively because of its potential function in the development and regulation of the immune system. The IL-2R alpha chain has been shown to be expressed on CD4-CD8- thymocytes and activated T and B cells. In this report, we show that IL-2R alpha is also expressed on precursor B cells in the bone marrow. Its expression is initiated by functional rearrangement and expression of Ig mu heavy chain gene and is down-regulated when immature B cells mature and express IgD. Its potential function in early B cell differentiation is discussed in comparison with its role in thymocyte differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • Bone Marrow Cells
  • Cell Differentiation / immunology
  • Mice
  • Mice, Mutant Strains
  • Mice, Transgenic
  • Receptors, Interleukin-2 / biosynthesis*
  • Receptors, Interleukin-2 / chemistry


  • Receptors, Interleukin-2