A test of the Markovian model of DNA evolution

Biometrics. 1994 Sep;50(3):653-64.

Abstract

The Markov model of molecular evolution has recently received a significant amount of interest because its statistical nature allows for the testing of a number of evolutionary hypotheses. Here we propose a test which assesses whether data from two species sharing a common ancestor will fit a general Markovian model. We illustrate the test with two examples of data which appear at first glance not to fit a Markov model.

MeSH terms

  • Animals
  • Biological Evolution*
  • Biometry
  • DNA / chemistry
  • DNA / genetics*
  • Humans
  • Markov Chains*
  • Mathematics
  • Models, Genetic*
  • Models, Statistical

Substances

  • DNA