HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

Nat Genet. 1993 Apr;3(4):358-64. doi: 10.1038/ng0493-358.


The role of HLA class II alleles in genetic predisposition to insulin dependent diabetes mellitus (IDDM) was examined by PCR/oligonucleotide probe typing of 42 Mexican-American IDDM families derived from Hispanic Caucasians and Native Americans. All high risk haplotypes (HLA-DR3 and DR4) were of European origin while the most strongly protective haplotype (DRB1*1402) was Native American. Of the 16 DR-DQ DR4 haplotypes identified, only those bearing DQB1*0302 conferred risk; the DRB1 allele, however, also markedly influenced IDDM risk. The general pattern of neutral and protective haplotypes indicates that the presence of Asp-57 in the HLA-DQ beta chain does not confer IDDM protection per se and indicates that both DRB1 and DQB1 influence IDDM susceptibility as well as protection.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Diabetes Mellitus, Type 1 / epidemiology
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / immunology*
  • Gene Frequency
  • Genetic Predisposition to Disease
  • HLA-D Antigens / genetics*
  • HLA-DQ Antigens / genetics
  • HLA-DR Antigens / genetics
  • Haplotypes
  • Histocompatibility Antigens Class II*
  • Humans
  • Immunity, Innate / genetics
  • Mexican Americans / genetics*
  • Mexico / ethnology
  • Pedigree
  • Polymerase Chain Reaction
  • Reference Values
  • Risk Factors
  • United States
  • White People / genetics


  • HLA-D Antigens
  • HLA-DQ Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II