Lipoprotein(a) as a correlate of stroke and transient ischemic attack prevalence in a biracial cohort: the ARIC Study. Atherosclerosis Risk in Communities

Ann Epidemiol. 1994 Sep;4(5):351-9. doi: 10.1016/1047-2797(94)90068-x.

Abstract

Although both mean lipoprotein(a) [Lp(a)] concentration and national stroke prevalence estimates are consistently higher in American blacks than in whites, no information exists on the relationship of Lp(a) and stroke prevalence in African-Americans. Associations of Lp(a) with stroke or transient ischemic attack (TIA) are addressed in this report for 15,160 participants--4160 blacks and 11,000 whites--in the Atherosclerosis Risk in Communities (ARIC) Study. Lp(a) was measured in ARIC as its total protein component by double-antibody enzyme-linked immunosorbent assay (ELISA) for apo(a) detection. Self-reported stroke/TIA history was assessed as part of a standardized questionnaire, and resulted in age-adjusted stroke/TIA prevalences of 3.0% in blacks (n = 120) and 2.0% in whites (n = 222). Overall, mean Lp(a) protein levels were markedly higher for blacks than for whites (160.5 versus 81.6 micrograms/mL, respectively), and were statistically significantly higher among individuals reporting stroke/TIA history for both races (191.3 versus 159.6 micrograms/mL in blacks; 100.6 versus 81.2 micrograms/mL in whites). Multivariable logistic regression analysis for the association of Lp(a) protein with stroke/TIA status yielded a prevalence odds ratio (OR) (95% confidence intervals) of 1.17 (1.05, 1.30) overall (based on one standard deviation difference, 108.2 micrograms/mL, in Lp[a] protein). Race-specific ORs, after adjustment for the same covariates, were equivalent for blacks [OR = 1.17 (0.99, 1.39)] and whites [OR = 1.19 (1.04, 1.36)]. These data suggest that Lp(a) is an independent risk factor for stroke/TIA in both blacks and whites, and that the relative risk of stroke/TIA associated with Lp(a) protein does not vary by race.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Americans
  • Cerebrovascular Disorders / blood*
  • Cerebrovascular Disorders / epidemiology*
  • Cerebrovascular Disorders / ethnology
  • Cohort Studies
  • Confidence Intervals
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay
  • European Continental Ancestry Group
  • Female
  • Humans
  • Ischemic Attack, Transient / blood*
  • Ischemic Attack, Transient / epidemiology
  • Ischemic Attack, Transient / ethnology
  • Lipoprotein(a) / blood*
  • Male
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Regression Analysis
  • Risk
  • Risk Factors
  • United States / epidemiology

Substances

  • Lipoprotein(a)