Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis

Magn Reson Med. 1994 Sep;32(3):285-93. doi: 10.1002/mrm.1910320303.


Magnetization transfer imaging (MT) and localized proton spectroscopy (1H-MRS) were utilized in the evaluation of lesions (high signal abnormalities on T2-weighted images) and normal-appearing white matter (NAWM) in multiple sclerosis (MS). Eleven patients with a clinical diagnosis of MS were independently evaluated with both 1H-MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of N-acetyl-aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed "marker peaks." The MTR of white matter lesions in the MS patients was markedly decreased (6-34%; normal approximately 42%), and correlated well with increase in the marker peaks region (0.94-3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aspartic Acid / analogs & derivatives
  • Aspartic Acid / metabolism
  • Brain / metabolism
  • Brain / pathology*
  • Choline / metabolism
  • Cohort Studies
  • Creatine / metabolism
  • Demyelinating Diseases / diagnosis*
  • Demyelinating Diseases / metabolism
  • Demyelinating Diseases / pathology
  • Humans
  • Hydrogen
  • Image Enhancement / methods
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy* / methods
  • Middle Aged
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / metabolism
  • Multiple Sclerosis / pathology
  • Phosphocreatine / metabolism
  • Signal Processing, Computer-Assisted


  • Phosphocreatine
  • Aspartic Acid
  • Hydrogen
  • N-acetylaspartate
  • Creatine
  • Choline