Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 Tesla

Magn Reson Med. 1994 Sep;32(3):335-41. doi: 10.1002/mrm.1910320309.


In this paper a new method is presented for the relative assessment of brain iron concentrations based on the evaluation of T2 and T2*-weighted images. A multiecho sequence is employed for rapid measurement of T2 and T2*, enabling calculation of the line broadening effect (T2'). Several groups have failed to show a correlation between T2 and brain iron content. However, quantification of T2', and the associated relaxation rate R2', may provide a more specific relative measure of brain iron concentration. This may find application in the study of brain diseases, which cause associated changes in brain iron levels. A new method of field inhomogeneity correction is presented that allows the separation of global and local field inhomogeneities, leading to more accurate T2* measurements and hence, T2' values. The combination of T2*, and T2-weighted MRI methods enables the differentiation of Parkinson's disease patients from normal age-matched controls based on differences in iron content within the substantia nigra.

MeSH terms

  • Aged
  • Algorithms
  • Brain Chemistry*
  • Case-Control Studies
  • Female
  • Humans
  • Image Enhancement / methods*
  • Iron / analysis*
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy / methods
  • Male
  • Middle Aged
  • Parkinson Disease / metabolism
  • Substantia Nigra / chemistry


  • Iron