Transient intercellular adhesion: the importance of weak protein-protein interactions

Trends Biochem Sci. 1994 Sep;19(9):354-8. doi: 10.1016/0968-0004(94)90109-0.


Intercellular adhesion is a complex phenomenon central to the development, structure and functioning of all multicellular organisms. Adhesion is mediated by distinct families of cell-adhesion molecules (CAMs), and recent studies have identified key characteristics of CAMs that influence their function. Affinity and kinetic analyses using a novel technique based on surface plasmon resonance have shown that CAM interactions that mediate transient cell adhesion may have surprisingly low affinities and extremely fast dissociation rate constants.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Adhesion
  • Cell Adhesion Molecules / physiology*
  • Cell Communication / physiology
  • Protein Binding / physiology*


  • Cell Adhesion Molecules