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, 38 (8), 1864-7

Efficacy of 2'-deoxy-2'-fluororibosides Against Influenza A and B Viruses in Ferrets

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Efficacy of 2'-deoxy-2'-fluororibosides Against Influenza A and B Viruses in Ferrets

K J Jakeman et al. Antimicrob Agents Chemother.

Abstract

Single-dose treatments (5 to 40 mg/kg of body weight given intraperitoneally) of ferrets with 2'-deoxy-2'-fluoroguanosine or its prodrug, 2,6-diamino-purine-2'-fluororiboside, 1 h after infection with influenza A virus significantly inhibited replication of virus in the upper respiratory tract, resulting in amelioration of fever and nasal inflammation. Replication of virus in the lower respiratory tract was also reduced > 100-fold, but three doses were required to prevent replication in the lungs. In ferrets infected with influenza B virus, single-dose treatment (40 mg/kg given intraperitoneally) produced a similar but reduced response in comparison with that in ferrets infected with influenza A virus, indicating that dosing was not optimal for this virus.

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