Long-term HIV-1 Infection Without Immunologic Progression

AIDS. 1994 Aug;8(8):1123-8. doi: 10.1097/00002030-199408000-00014.

Abstract

Objective: To identify and describe a subgroup of men infected with HIV for 10-15 years without immunologic progression, and to evaluate the effect of sexually transmitted diseases (STD) and recreational drug use on delayed HIV disease progression.

Design: Inception cohort study.

Setting: Municipal STD clinic.

Participants: A total of 588 men with well documented dates of HIV seroconversion and 197 HIV-seronegative controls.

Main outcome measures: AIDS, CD4+ count, rate of CD4+ cell loss, CD8+ count, beta 2-microglobulin, complete blood count, p24 antigen and HIV-related symptoms.

Results: Of 588 men, 69% had developed AIDS by 14 years after HIV seroconversion (95% confidence interval, 64-73%). Of 539 men with HIV seroconversion dates prior to 1983, 42 men (8%) were healthy long-term HIV-positives (HLP), HIV-infected > or = 10 years without AIDS and with CD4+ counts > 500 x 10(6)/l. When compared with progressors (men with HIV seroconversion prior to 1983 but with AIDS or CD4+ counts < 200 x 10(6)/l), HLP had a significantly slower rate of CD4+ decline (6 versus 85 x 10(6)/l cells/year), and less abnormal immunologic, hematologic and clinical parameters. However, when compared with HIV-uninfected controls, HLP demonstrated lower CD4+ counts and mild hematologic abnormalities. There were no consistent differences between HLP and progressors in prior exposure to recreational drugs or STD.

Conclusion: There are individuals with long-term HIV infection who appear clinically and immunologically healthy 10-15 years after HIV seroconversion, with stable CD4+ counts. Lack of exposure to STD or recreational drugs does not appear to explain the delayed course of disease progression in HLP.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / epidemiology
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / physiopathology*
  • CD4 Lymphocyte Count
  • CD8-Positive T-Lymphocytes / immunology
  • Cohort Studies
  • HIV Seronegativity / immunology*
  • HIV Seropositivity / blood
  • HIV Seropositivity / immunology
  • HIV Seropositivity / physiopathology*
  • HIV-1*
  • Humans
  • Incidence
  • Lymphocyte Count
  • Male
  • San Francisco / epidemiology
  • Time Factors
  • beta 2-Microglobulin / analysis

Substances

  • beta 2-Microglobulin