Ingested mutagens from opium and tobacco pyrolysis products and cancer of the oesophagus

Lancet. 1978 Sep 2;2(8088):494-6. doi: 10.1016/s0140-6736(78)92218-3.

Abstract

Substances which are commonly sucked or chewed in two areas where the incidence of oesophageal cancer is high, the Transkei and north-east Iran, were tested in bacterial mutagenicity assays. Pyrolysed substances, opium dross in north-east Iran and tobacco pipe residues in the Transkei, displayed mutagenic activity in Salmonella typhimurium strains TA98 and TA100 in the presence of rat liver microsomes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Adult
  • Animals
  • Cells, Cultured
  • Esophageal Neoplasms / chemically induced*
  • Female
  • Humans
  • Iran
  • Male
  • Microsomes, Liver
  • Mutagens* / administration & dosage
  • Mutation / drug effects
  • Opium / administration & dosage
  • Opium / adverse effects*
  • Plants, Toxic*
  • Rats
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Smoking / complications*
  • South Africa
  • Tobacco*

Substances

  • Mutagens
  • Opium