Hypercalcaemia in B cell chronic lymphocytic leukaemia

Br J Haematol. 1994 Aug;87(4):856-8. doi: 10.1111/j.1365-2141.1994.tb06752.x.


Hypercalcaemia is common in some lymphoproliferative disorders such as myeloma or T-cell leukaemia-lymphoma, but is rarely described in B cell chronic lymphocytic leukaemia (BCLL). We report the case of a patient with BCLL, hypercalcaemia and osteolytic bone lesions. Parathyroid hormone-related protein (PTHrP) mRNA was identified by Northern blot analysis of liver, spleen and lymph node tumour samples. Serum levels of tumour necrosis factor alpha (TNF alpha) were increased.

Publication types

  • Case Reports

MeSH terms

  • Blotting, Northern
  • Humans
  • Hypercalcemia / etiology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications*
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism
  • Male
  • Middle Aged
  • Neoplasm Proteins / biosynthesis
  • Paraneoplastic Syndromes / etiology*
  • Parathyroid Hormone-Related Protein
  • Protein Biosynthesis
  • RNA, Messenger / genetics
  • RNA, Neoplasm / genetics
  • Tumor Necrosis Factor-alpha / analysis


  • Neoplasm Proteins
  • PTHLH protein, human
  • Parathyroid Hormone-Related Protein
  • RNA, Messenger
  • RNA, Neoplasm
  • Tumor Necrosis Factor-alpha