Agenesis of corpus callosum and dementia of the Alzheimer's type: a review and case report

Can J Psychiatry. 1994 Sep;39(7):429-32. doi: 10.1177/070674379403900707.


This paper describes a previously sufficiently functioning 57 year old man who presented with a recent onset of frontal behaviour. Partial agenesis of corpus callosum was an incidental finding on a computerized tomography scan. The EEG was within normal limits and neuropsychological testing did not reveal any interhemispheric disconnection. A SPECT-Scan revealed bilateral hypoperfusion, consistent with Alzheimer's dementia. Normal functioning up to 50 years of age and a later manifestation of Alzheimer's disease along with agenesis of carpus callosum is of clinical interest as such an association has not been published.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Agenesis of Corpus Callosum*
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / psychology
  • Cerebral Cortex / blood supply
  • Dominance, Cerebral / physiology
  • Electroencephalography
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Regional Blood Flow / physiology
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, X-Ray Computed