Low-grade glial neoplasms and intractable partial epilepsy: efficacy of surgical treatment

Epilepsia. Nov-Dec 1994;35(6):1130-5. doi: 10.1111/j.1528-1157.1994.tb01778.x.

Abstract

We performed a retrospective study of 51 consecutive patients who underwent operation for intractable partial epilepsy related to low-grade intracerebral neoplasms between 1984 and 1990. All patients had medically refractory partial seizures and a mass lesion identified on neuroimaging studies. Lesionectomy was performed on 17 patients, and 34 had lesion resection and corticectomy. Mean postoperative follow-up was 4.4 years (range 2-8 years). Sixty-six percent of patients were seizure-free, and 88% experienced a significant reduction in seizure frequency. In 16 patients (31%), antiepileptic drugs (AEDs) were successfully discontinued. Twenty-five of 31 (81%) eligible patients obtained a driver's license after successful operation. Patients with complete tumor resection and no interictal epileptiform activity on postoperative EEG studies had the best operative outcome. Epilepsy surgery can result in long-term improvement in seizure control and quality of life (QOL) in selected patients with intractable tumor-related epilepsy. Our results should be useful to clinicians considering treatment options for patients with intractable seizures related to low-grade intracerebral neoplasms.

MeSH terms

  • Adolescent
  • Adult
  • Brain Neoplasms / complications
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / surgery*
  • Cerebral Cortex / physiopathology
  • Cerebral Cortex / surgery
  • Child
  • Child, Preschool
  • Electroencephalography
  • Epilepsies, Partial / diagnosis
  • Epilepsies, Partial / etiology
  • Epilepsies, Partial / surgery*
  • Female
  • Follow-Up Studies
  • Glioma / complications
  • Glioma / diagnosis
  • Glioma / surgery*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Postoperative Complications / diagnosis
  • Postoperative Complications / etiology
  • Quality of Life
  • Retrospective Studies
  • Tomography, X-Ray Computed
  • Treatment Outcome