Developmental regulation of gene expression for the MPTP delta isoforms in the central nervous system and the immune system

FEBS Lett. 1994 Dec 5;355(3):223-8. doi: 10.1016/0014-5793(94)01188-5.


MPTP delta is a murine transmembrane protein tyrosine phosphatase which has three isoforms, types A-C, differing in the structure of the extracellular regions. In this study, we examined MPTP delta isoform expression in the brain and the immune system at discrete developmental or differentiation stages. RT-PCR analysis demonstrated that another isoform, type D, is transcribed from the MPTP delta gene. In the brain, only type D was expressed until postnatal day 7 (P7), but after P14, all four isoforms were detected. In contrast, the spleen, thymus and all the hematopoietic cell lines examined express only types B and C isoforms. An in situ hybridization study showed that MPTP delta mRNA is diffusely expressed throughout the spleen, but its expression in the thymus is restricted to the medullary region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes
  • Base Sequence
  • Brain / cytology
  • Brain / growth & development
  • Brain / immunology
  • Brain / metabolism*
  • Cell Differentiation
  • Female
  • Gene Expression Regulation*
  • Genetic Variation*
  • Hematopoietic Stem Cells / metabolism
  • Immune System / metabolism*
  • In Situ Hybridization
  • Lymphoid Tissue / cytology
  • Lymphoid Tissue / growth & development
  • Lymphoid Tissue / metabolism
  • Macrophages
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Pregnancy
  • Protein Tyrosine Phosphatases / biosynthesis*
  • Protein Tyrosine Phosphatases / classification
  • Protein Tyrosine Phosphatases / genetics
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2


  • Protein Tyrosine Phosphatases
  • Ptprd protein, mouse
  • Receptor-Like Protein Tyrosine Phosphatases, Class 2