Clinical application and quantitative evaluation of generator-produced copper-62-PTSM as a brain perfusion tracer for PET

J Nucl Med. 1994 Dec;35(12):1910-5.


Copper-62-pyruvaldehyde bis(N4-methylthiosemicarbazone) copper II (62Cu-PTSM) has been proposed as a generator-produced positron-emitting tracer for perfusion imaging. To evaluate the characteristics of 62Cu-PTSM as a cerebral perfusion tracer, brain PET images of 62Cu-PTSM were compared with cerebral blood flow (CBF).

Methods: Following an intravenous injection of 62Cu-PTSM, a serial dynamic PET scan was performed for 10 min with arterial sampling in 10 subjects. CBF was measured by 15O-labeled water before the 62Cu-PTSM study.

Results: Dynamic PET scan with octanol-extracted arterial input function indicated the presence of significant back-diffusion of 62Cu-PTSM from the brain within 3 min after injection, followed by stable activity from 3 to 10 min. Comparison with 15O-water PET demonstrated less contrast between high- and low-flow regions in 62Cu-PTSM image and a nonlinear relationship of flow and 62Cu-PTSM uptake, which suggests the underestimation of CBF in high-flow regions due to the existence of back-diffusion.

Conclusion: Although 62Cu-PTSM can be used widely for evaluation of brain perfusion with PET, kinetic analysis and correction may be needed to quantify regional CBF.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Brain / blood supply
  • Brain / diagnostic imaging
  • Cerebrovascular Circulation*
  • Copper Radioisotopes*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Organometallic Compounds*
  • Perfusion
  • Thiosemicarbazones*
  • Tomography, Emission-Computed*


  • Copper Radioisotopes
  • Organometallic Compounds
  • Thiosemicarbazones
  • copper pyruvaldehyde bis(N(4)-methylthiosemicarbazone) complex