Isolated motor control dysfunction related to progressive multifocal leukoencephalopathy during AIDS with normal MRI

Neurology. 1994 Dec;44(12):2352-5. doi: 10.1212/wnl.44.12.2352.


We describe the case of a human immunodeficiency virus-infected 34-year-old man with progressive multifocal leukoencephalopathy (PML). His case displayed unusual features, including a bizarre movement disorder, predominant involvement of the subcortical U fibers on neuropathologic examination, and the absence of MRI abnormalities suggestive of PML. Anatomic-clinical correlations are discussed.

Publication types

  • Case Reports

MeSH terms

  • AIDS Dementia Complex / pathology*
  • AIDS Dementia Complex / physiopathology*
  • Acquired Immunodeficiency Syndrome / pathology
  • Acquired Immunodeficiency Syndrome / physiopathology*
  • Adult
  • Brain / pathology*
  • Brain / virology
  • Fatal Outcome
  • Humans
  • In Situ Hybridization
  • JC Virus / isolation & purification
  • Magnetic Resonance Imaging
  • Male
  • Movement Disorders / pathology
  • Movement Disorders / physiopathology*
  • Reference Values