Melanocortins as factors in somatic neuromuscular growth and regrowth

Pharmacol Ther. Apr-May 1994;62(1-2):1-27. doi: 10.1016/0163-7258(94)90002-7.

Abstract

Melanocortins, non-corticotropic fragments of adrenocorticotropic hormone, accelerate growth of the developing neuromuscular system and regrowth of damaged neurons, both in the adult and neonatal rat. Morphological, electrophysiological and behavioral characteristics are all improved by melanocortins, which, however, vary in potency, with alpha-MSH being the most effective. Tissue substrate, dosage, critical time periods and pattern of neuropeptide administration are all important variables. Melanocortins protect central neurons affecting motor behavior during development or following neuronal damage in the adult brain. Possible mechanisms of melanocortin action are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenocorticotropic Hormone / chemistry
  • Adrenocorticotropic Hormone / pharmacology
  • Adrenocorticotropic Hormone / physiology*
  • Amino Acid Sequence
  • Animals
  • Animals, Newborn
  • Cells, Cultured
  • Electrophysiology
  • Humans
  • Molecular Sequence Data
  • Motor Activity / drug effects*
  • Muscle Development
  • Muscles / drug effects
  • Muscles / innervation*
  • Nerve Regeneration / drug effects
  • Neuromuscular Agents / administration & dosage
  • Neuromuscular Agents / pharmacology*
  • Neuromuscular Agents / therapeutic use
  • Neuromuscular Junction / drug effects
  • Neurons / cytology
  • Neurons / drug effects
  • Neurons / physiology
  • Rats
  • Receptors, Corticotropin / drug effects
  • Receptors, Corticotropin / metabolism
  • Structure-Activity Relationship

Substances

  • Neuromuscular Agents
  • Receptors, Corticotropin
  • Adrenocorticotropic Hormone