A multidimensional approach to analysis of cerebrospinal fluid biogenic amines in schizophrenia: II. Correlations with psychopathology

Psychiatry Res. 1994 Jun;52(3):251-8. doi: 10.1016/0165-1781(94)90070-1.


As part of a multidimensional study of cerebrospinal fluid biogenic amine metabolites in schizophrenia, the relationship between neurochemical measures and psychopathology assessed using the Psychiatric Symptom Assessment Scale (PSAS) was analyzed. In a group of 20 unmedicated patients, 3,4-dihydroxyphenylacetic acid (DOPAC) was a predictor of symptom severity in a stepwise multiple regression model. Values of 3-hydroxykynurenine and metanephrine in the unmedicated state predicted clinical response in a stepwise multiple regression model, as measured by improvement in PSAS mean item score following 6 weeks on a standard dose of neuroleptic. In a subgroup of 14 patients in whom both off- and on-medication concentrations of cerebrospinal fluid biogenic amines and metabolites were measured, change in 3-hydroxykynurenine predicted clinical outcome in a multiple regression model. These findings point toward the need to examine the role of the kynurenine pathway of tryptophan metabolism in the pathophysiology of schizophrenia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Biogenic Amines / cerebrospinal fluid*
  • Dopamine / cerebrospinal fluid
  • Double-Blind Method
  • Female
  • Haloperidol / therapeutic use*
  • Humans
  • Kynurenine / cerebrospinal fluid
  • Male
  • Norepinephrine / cerebrospinal fluid
  • Psychiatric Status Rating Scales
  • Schizophrenia / cerebrospinal fluid
  • Schizophrenia / diagnosis
  • Schizophrenia / drug therapy*
  • Schizophrenic Psychology*
  • Serotonin / cerebrospinal fluid
  • Tryptophan / cerebrospinal fluid
  • Tyrosine / cerebrospinal fluid


  • Biogenic Amines
  • Serotonin
  • Kynurenine
  • Tyrosine
  • Tryptophan
  • Haloperidol
  • Dopamine
  • Norepinephrine